pentobarbital will lower the extent or influence of alfentanil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unidentified.pentobarbital will reduce the extent or impact of ixabepilone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.Contraindicated. Coadministration of doravirine wit